Tretinoin and Benzoyl Peroxide
نویسندگان
چکیده
A simple, sensitive, spectrophotometric method in UV region has been developed for the simultaneous estimation of benzoyl peroxide and tretinoin in bulk and semi solid dosage form (cream). Standard solution of benzoyl peroxide shows maximum absorbance at 234.8 nm and tretinoin shows maximum absorbance at 348.6 nm. Beer’s Lamberts law is obeyed in concentration range 1-9 μg/ml for tretinoin with regression, slope and intercept of 0.991, 0.0918 and 0 respectively while for benzoyl peroxide, Beer’s Lambert law is obeyed in concentration range 0.5-5 μg/ml with regression, slope and intercept having 0.9984, 0.2069 and 0.0253 respectively. Method was validated for linearity, range, accuracy, precision, recovery studies and interference study of mixture. All these parameters showed the adaptability of the method for the quality control analysis of the drug in bulk and in combination formulations.
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